Analysis of methylation of a human X located gene which escapes X inactivation.
نویسندگان
چکیده
The gene MIC2 is located in the pseudoautosomal region at the ends of the short arms of the X and Y chromosomes. In females MIC2 escapes X inactivation. We have analyzed the methylation pattern of MIC2 on the active X, the inactive X chromosomes, and the Y chromosome. The 5' end of the gene contains a GC rich region which is unmethylated on the active X, the inactive X and on the Y. The body of the gene is characterized by variable methylation.
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عنوان ژورنال:
- Nucleic acids research
دوره 16 14B شماره
صفحات -
تاریخ انتشار 1988